Practice question · Put in order
Arrange the stages of the secretory pathway in order.
- Processing and sorting through the Golgi stack
- Transport by vesicle to the Golgi cis face
- Release at the plasma membrane by exocytosis
- Folding and initial modification in the ER lumen
- Synthesis by a ribosome on the rough endoplasmic reticulum
Hints
- The route runs from the site of synthesis outward.
- The Golgi is entered at the cis face and left at the trans face.
Show the answer
- Synthesis by a ribosome on the rough endoplasmic reticulum
- Folding and initial modification in the ER lumen
- Transport by vesicle to the Golgi cis face
- Processing and sorting through the Golgi stack
- Release at the plasma membrane by exocytosis
Why
The route is strictly ordered, and each stage does something the next depends on. Sugar tags added in the Golgi are the address labels that determine where the vesicle goes, so sorting cannot precede glycosylation.
Practise The Endomembrane System
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