Practice question · Multiple choice
In connective tissues, matrix determines functional properties rather than the cellular content. How does this structural principle explain why bone can actively remodel under mechanical stress while cartilage cannot?
Hints
- What infrastructural support does active, ongoing tissue turnover require?
- How does the vascularity of a tissue relate to the physical organisation of its matrix?
Show the answer
A. A mineralised matrix permits vascular channels that supply remodelling cells
Why
Remodelling requires continuous nutrient delivery and cell turnover via blood vessels, which bone's rigid architecture accommodates through canal systems. Cartilage's avascular, gel matrix relies solely on slow diffusion, preventing rapid cellular adaptation.
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