Practice question · Multiple choice
An inhibitory synapse sits on the axon hillock. An excitatory synapse producing a potential of exactly the same size sits far out on a distal dendrite. Why does the inhibitory one have the greater influence on whether the neuron fires?
Hints
- Both potentials have to travel to the same place before either can matter. Ask what happens to them on the way.
- The decision is taken at the axon hillock. Which input has further to go?
Show the answer
C. Because postsynaptic potentials shrink as they spread.
Why
Postsynaptic potentials are passive and leak away as they spread, so two equal potentials are no longer equal by the time they reach the axon hillock where the decision is taken. It is why inhibitory synapses cluster on the soma, anatomy is doing arithmetic, and position counts alongside amplitude.
Practise Synaptic Transmission
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